8/9/2011
Saiu o JBCS número 9 - Volume 22
O JBCS acaba de lançar online seu nono número de 2011 (vol. 22-9, correspondente a Setembro). A impressão e, portanto, distribuição da revista aos assinantes ocorrerá em breve.
Neste novo número, ilustrando nosso novo design de capa, temos o Article Study of the BPP7a Peptide and its ß-Cyclodextrin Complex: Physicochemical Characterization and Complete Sequence Specific NMR Assignments dos autores Ivana Lula, Frederico B. de Sousa, Ângelo M. L. Denadai, Danielle Ianzer, Antônio C. M. de Camargo, Robson A. S. Santos and Rubén D. Sinisterra. O texto editorial de autoria de Nancy B. Jackson é presidente da Sociedade Americana trata da "Importância da Colaboração Internacional para a Química do Século XXI". Ao todo, o JBCS vol. 22, No. 9 apresenta 206 páginas impressas, contendo 25 Artigos.
Assinem, e divulguem o JBCS. Façam um link de nossa página em sua instituição, laboratório ou empresa já que o acesso é aberto. Incentivem a leitura, pesquisa e citação ao JBCS.
Fonte: Elizabeth Magalhaes (JBCS)
Table of Contents with Graphical Abstracts
Study of the BPP7a Peptide and its β-Cyclodextrin Complex: Physicochemical Characterization and Complete Sequence Specific NMR Assignments |
| Ivana Lula, Frederico B. de Sousa, Ângelo M. L. Denadai, Danielle Ianzer, Antônio C. M. de Camargo, Robson A. S. Santos and Rubén D. Sinisterra |
 BPP7a, a small peptide molecule from Bothrops jararaca venon, shows a potent and sustained antihypertensive activity in vivo, which may lead to the development of new antihypertensive drugs. Peptides are preferentially absorbed in the colon after oral administration, and cyclodextrins shows a great potential as colon-specific drug carrier system, minimizing the possible drawbacks associated with drug degradation. Thus, a synergic effect could be reached using cyclodextrins as drug carrier systems for peptides molecules. In vivo experiments showed that BPP7a complexation with β-cyclodextrin increased considerably the antihypertensive activity previously observed for the free peptide. |
NMR spectroscopy has been used as an important tool in order to obtain deep information regarding peptide structure, self-aggregation and also its interaction with cyclodextrins. Moreover, diffusion ordered spectroscopy experiments (DOSY NMR) were essential to prove the interaction between host and guest molecules and confirming the complex formation. Details are discussed in the article Study of the BPP7a Peptide and its β-Cyclodextrin Complex: Physicochemical Characterization and Complete Sequence Specific NMR Assignments by Ivana Lula et al. on page 1765.
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>> Editorial(208 KB)
The Importance of International Collaborations for the 21st Century Chemist
Nancy B. Jackson |
| J. Braz. Chem. Soc. 2011, 22, 1617. |
Modulation of the Catalytic Activity of Porphyrins by Lipid- and Surfactant-Containing Nanostructures |
Iseli L. Nantes, Nelson Durán, Sandra M. S. Pinto, Fabiana B. da Silva, Juliana S. de Souza,
Noemia Isoda, Roberto A. S. Luz, Tiara G. de Oliveira and Vinícius G. Fernandes |
| J. Braz. Chem. Soc. 2011, 22, 1621. |
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| The structure and activity of metaloporphyrins are modulated by axial and equatorial ligands (highlighted as red circles), by solvents (top left corner), by the microenvironments provided by apoproteins (right bottom corner) and by the association to surfactant- and lipid -containing nanostructures such as micelles and liposomes |
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Web Release date: May 26, 2011. |
Microwave-Promoted Morita-Baylis-Hillman Reactions: Efficient Synthesis of New Monoacylglycerols (MAGs) as Potential Anti-Parasitic Compounds |
| Suervy C. O. Sousa, Claudio G. L. Junior, Fábio P. L. Silva, Natália G. Andrade, Ticiano P. Barbosa and Mário L. A. A. Vasconcellos |
| J. Braz. Chem. Soc. 2011, 22, 1634. |
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| The new congeners hydrophilic MAGs and the corresponding synthetic precursors were prepared in high yields (67-90%, one or two steps) under microwave irradiation using glycerol derivatives as starting materials. These are a new potential antiparasitic compounds |
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Web Release date: June 2, 2011. |
Characterization Studies of 1-(4-Cyano-2-oxo-1,2-dihydro-1- pyridyl)-3-(4-cyano-1,2-dihydro-1-pyridyl)propane Formed from the Reaction of Hydroxide Ion with 1,3-Bis-(4-cyano pyridinium)propane |
Simone Fiori, Ivânia T. A. Schuquel, Idélcio N. da Silva, Mário J. Politi, Luiz H. Catalani,
Hernan Chaimovich, Emerson Meyer and Noboru Hioka |
| J. Braz. Chem. Soc. 2011, 22, 1644. |
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| The alkaline hydrolysis of bis(4-cyanopyridinium) salts with two pyridinium rings covalently linked by methylene spacers produce compounds constituted by 4-pyridone and 4-carboxamidopyridinium rings. However, the reactant with three methylene groups additionally generates a new product promoted by charge-conformational effects |
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Web Release date: June 7, 2011. |
Bromine and Chlorine Determination in Cigarette Tobacco using Microwave-Induced Combustion and Inductively Coupled Plasma Optical Emission Spectrometry |
Aline L. H. Müller, Cezar A. Bizzi, Juliana S. F. Pereira, Marcia F. Mesko, Diogo P. Moraes,
Erico M. M. Flores and Edson I. Muller |
| J. Braz. Chem. Soc. 2011, 22, 1649. |
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| Microwave-induced combustion was applied for cigarette tobacco samples digestion and further determination of bromine and chlorine by inductively coupled plasma optical emission spectrometry (ICP OES). In addition, it was possible to obtain a single solution suitable for both analytes determination using different analytical techniques and with residual carbon content lower than 1% |
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Web Release date: June 7, 2011. |
Microextraction in Packed Sorbent for Determination of Sulfonamides in Egg Samples by Liquid Chromatography and Spectrophotometric Detection |
| Fernanda H. Salami and Maria Eugênia C. Queiroz |
| J. Braz. Chem. Soc. 2011, 22, 1656. |
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| Microextraction by packed sorbent (MEPS) is the miniaturization of conventional solid phase extraction (SPE) packed bed devices from milliliter bed volumes to microliter volumes. MEPS can be connected online liquid chromatography (LC) without any modifications. In MEPS the sorbent, 1-2 mg, is either inserted into the syringe (100-250 μL) barrel as a plug or between the needle and the barrel as a cartridge |
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Web Release date: June 9, 2011. |
Determination of Efavirenz in Diluted Alkaline Electrolyte by Cathodic Adsorptive Stripping Voltammetry at the Mercury Film Electrode |
| Arnaldo A. Castro, Marcus V. N. de Souza, Nicolás A. Rey and Percio A. M. Farias |
| J. Braz. Chem. Soc. 2011, 22, 1662. |
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| A stripping method for the determination of the antiretroviral drug efavirenz at submicromolar concentration levels in diluted alkaline electrolyte is described. The utility of the method is demonstrated by the determination of efavirenz in a synthetic mixture containing both lamivudine and zidovudine |
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Web Release date: June 9, 2011. |
Effect of Temperature on Methylene Blue Decolorization in Aqueous Medium in Electrical Discharge Plasma Reactor |
Luís O. de B. Benetoli, Bruno M. Cadorin, Cícero da S. Postiglione, Ivan G. de Souza and
Nito A. Debacher |
| J. Braz. Chem. Soc. 2011, 22, 1669. |
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| The non-thermal plasma experimental setup. The increasing need for clean water has motivated the development of new technologies for water cleaning. Non-thermal plasma can be efficiently applied to a large variety of environmental and industrial processes, in both the aqueous and gaseous phase, and it can be considered as a green technology, that is, less harmful to ecosystems than conventional technologies |
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Web Release date: June 9, 2011. |
SPE-HPLC Method for Determination of Ketoconazole and Clotrimazole Residues in Cow’s Milk |
| Farzaneh Ahmad Khan Beigi, Mohammad Imani, Mahmood Payehghadr and Hedayat Hosseini |
| J. Braz. Chem. Soc. 2011, 22, 1679. |
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In this article, a cheap, simple and reliable method is reported for enrichment and determination of ketoconazole and clotrimazole antifungal residues in cow’s milk. Extraction was accomplished using solid phase extraction and samples were subsequently analyzed by HPLC-UV method |
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Web Release date: June 9, 2011. |
Galvanostatic Removal of Pb2+ Ions from Diluted Solutions by the Use of a Membrane-Less Flow-Through Cell with Stainless Steel Wool Electrodes |
| Lucio C. Almeida, Nerilso Bocchi, Romeu C. Rocha-Filho and Sonia R. Biaggio |
| J. Braz. Chem. Soc. 2011, 22, 1686. |
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| The proposed electrolytic system led to the removal of the Pb2+ ions from dilute solutions by simultaneous reduction and oxidation in the cathodes and anode. Consequently, significant improvements of the current efficiency and Pb2+ fractional conversion (XPb2+) or decay of the normalized Pb2+ concentration (C/C0) were attained in a short time |
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Web Release date: June 9, 2011. |
The Effects of Solar Irradiation on Copper Speciation and Organic Complexation |
| Alessandra E. Tonietto, Ana Teresa Lombardi and Armando A. H. Vieira |
| J. Braz. Chem. Soc. 2011, 22, 1695. |
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| This research demonstrated that solar irradiation affected Cu speciation and Cu-DOM interactions in water samples from eutrophic and metal contaminated reservoir. It is a contribution to the understanding of the ecological implications of photooxidation in natural environments, such as the increase of Cu bioavailability |
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Web Release date: June 14, 2011. |
Determination of Pesticide Residues in Tomato using Dispersive Solid-Phase Extraction and Gas Chromatography/ Ion Trap Mass Spectrometry |
| Graziela C. R. Moura Andrade, Rosana M. O. Freguglia, Regina P. Z. Furlani, Nádia H. Torres and Valdemar L. Tornisielo |
| J. Braz. Chem. Soc. 2011, 22, 1701. |
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| A procedure based on dispersive solid-phase extraction was proposed to determine of pesticides in tomato samples. The method is a multi-class, quick, cheap and can be easily implemented for routine analysis. Different options in the protocol are possible depending on alternate analytical instrumentation available |
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Web Release date: June 14, 2011. |
Ethanol Electrooxidation using Ti/(RuO2)(x)Pt(1-x) Electrodes Prepared by the Polymeric Precursor Method |
R. G. Freitas, L. F. Q. P. Marchesi, M. R. Forim, L. O. S. Bulhões, E. C. Pereira, M. C. Santos and
R. T. S. Oliveira |
| J. Braz. Chem. Soc. 2011, 22, 1709. |
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| It was found that the best composition of the Ti/(RuO2)(x)Pt(1-x) electrodes prepared by the polymeric precursor method toward CO and ethanol electrooxidation processes is (x = 0.5). The onset for ethanol oxidation process is 220mV less positive than on Ti/Pt electrodes. The image shows the ethanol electrooxidation mechanism on Ti/(RuO2)(x)Pt(1-x) electrodes prepared by the polymeric precursor method |
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Web Release date: June 16, 2011. |
Descriptor- and Fragment-based QSAR Models for a Series of Schistosoma mansoni Purine Nucleoside Inhibitors |
| Humberto F. Freitas, Matheus P. Postigo, Adriano D. Andricopulo and Marcelo S. Castilho |
| J. Braz. Chem. Soc. 2011, 22, 1718. |
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Fragment- and descriptor-based QSAR models were employed to investigate the potency of a series of deazaguanine analogs as inhibitors of S. mansoni purine nucleoside phosphorylase. The HQSAR contribution maps highlight the contribution of the main fragments to potency (positive in green; detrimental in red)
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Web Release date: June 16, 2011. |
Fast and Simultaneous Determination of Pb2+ and Cu2+ in Water Samples using a Solid Paraffin-Based Carbon Paste Electrode Chemically Modified with 2-Aminothiazole-Silica-Gel |
| Daiane H. Silva, Dayane A. Costa, Regina M. Takeuchi and André L. Santos |
| J. Braz. Chem. Soc. 2011, 22, 1727. |
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| This work demonstrates that the combination of solid paraffin as binder agent and silica organofunctionalized with 2-aminothiazole groups as chemical modifier was a very efficient strategy to prepare highly stable carbon paste electrodes. These electrodes allowed in a reliable and simultaneous manner the low level quantification of Pb2+ and Cu2+ in water samples in a very fast way |
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Web Release date: June 21, 2011. |
Novel Chiral Ionic Liquid (CIL) Assisted Selectivity Enhancement to (L)-Proline Catalyzed Asymmetric Aldol Reactions |
| Long Zhang, Haibo Zhang, Huadong Luo, Xiaohai Zhou and Gongzhen Cheng |
| J. Braz. Chem. Soc. 2011, 22, 1736. |
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| A significant improvement of the chemical yields (up to 88%), stereoselectivity (> 99:1) and enantiomeric excesses (up to 98%) of (L)-proline catalyzed direct asymmetric aldol reaction was found when proline based chiral ionic liquids (CILs) were ued as additives |
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Web Release date: June 21, 2011. |
A "Green" Synthesis of N -(Quinoline-3-ylmethylene) benzohydrazide Derivatives and their Cytotoxicity Activities |
| LingamVenkata Reddy, Suresh Babu Nallapati, Syed Sultan Beevi, Lakshmi Narasu Mangamoori, Khagga Mukkanti and Sarbani Pal |
| J. Braz. Chem. Soc. 2011, 22, 1742. |
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| Synthesis of a range of hybrid molecules of potential pharmacological interest was accomplished via the reaction of 2-chloroquinoline-3-carbaldehyde with substituted hydrazides in a green and recyclable solvent PEG 400 |
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Web Release date: June 21, 2011. |
Organonickel(II) Complexes with Anionic Tridentate 1,3-Bis(azolylmethyl)phenyl Ligands. Synthesis, Structural Characterization and Catalytic Behavior |
| John Hurtado, Andrés Ibañez, René Rojas, Mauricio Valderrama and Roland Fröhlich |
| J. Braz. Chem. Soc. 2011, 22, 1750. |
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The synthesis of new ligands and organonickel pincer complexes has been described and their molecular structures were determined by single-crystal X-ray diffraction analysis. The nickel complex [NiBr{1,3-bis(indazolylmethyl)phenyl-N,C,N}] was tested as a catalyst in ethylene polymerization reaction under mild conditions |
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Web Release date: June 28, 2011. |
Analytical Methods in Photoelectrochemical Treatment of Phenol |
| Paulo R. M. Lopes, Renato N. Montagnolli and Ederio D. Bidoia |
| J. Braz. Chem. Soc. 2011, 22, 1758. |
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| When a semiconductor as TiO2 is irradiated by ultraviolet rays, electron/hole (e-/h+) pairs are formed in semiconductor surface and these reactions generate hydroxyl radicals. Hence, the highly oxidants species (OHo) are able to degrade organic compounds, such as phenols |
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Web Release date: June 28, 2011. |
Study of the BPP7a Peptide and its β-Cyclodextrin Complex: Physicochemical Characterization and Complete Sequence Specific NMR Assignments |
| Ivana Lula, Frederico B. de Sousa, Ângelo M. L. Denadai, Danielle Ianzer, Antônio C. M. de Camargo, Robson A. S. Santos and Rubén D. Sinisterra |
| J. Braz. Chem. Soc. 2011, 22, 1765. cover article |
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| The figure presents a structural proposal for the association complex formed between the BPP7a heptapeptide and β-cyclodextrin. The peptide and the BPP7a/β-cyclodextrin complex were characterized by circular dichroism, isothermal titration calorimetry and nuclear magnetic resonance spectroscopy |
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Web Release date: June 30, 2011. |
Property-Based Design and Synthesis of New Chloroquine Hybrids via Simple Incorporation of 2-Imino-thiazolidin- 4-one or 1H-Pyrrol-2,5-dione Fragments on the 4-Amino-7-chloroquinoline Side Chain |
| Fernando A. Rojas and Vladimir V. Kouznetsov |
| J. Braz. Chem. Soc. 2011, 22, 1774. |
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| New chloroquine based hybrids were designed in silico incorporating different small N-heterocycles on the side chain amino group, and finally synthesized in excellent yield by a straight forward synthetic methodology |
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Web Release date: June 30, 2011. |
Simultaneous Determination of Hydride and Non-Hydride Forming Elements by Inductively Coupled Plasma Optical Emission Spectrometry |
| Z. Benzo, M. N. Matos-Reyes, M. L. Cervera and M. de la Guardia |
| J. Braz. Chem. Soc. 2011, 22, 1782. |
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| A multielemental method based on the simultaneous determination of Ca, Cd, Co, Cr, Cu, Fe, Mg, Mo, Ni and Zn (non-hydride forming elements), and As, Bi, Sb, Se and Te (hydride forming elements) using a dual nebulizer and online hydride generation by axial view ICP OES has been developed and applied to the analysis of different reference materials |
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Web Release date: June 30, 2011. |
Use of Fe3+ Ion Probe to Study Intensively Weathered Soils utilizing Electron Paramagnetic Resonance and Optical Spectroscopy |
S. P. Balena, I. Messerschmidt, J. C. Tomazoni, E. Guimarães, B. F. Pereira, F. J. Ponzoni,
W. E. H. Blum and A. S. Mangrich |
| J. Braz. Chem. Soc. 2011, 22, 1788. |
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| Soil samples DRUV-VIS 2nd derivative K-M function. The name of hematite, α-Fe2O3, is related to the red color observed due to the strong d-d transition around 550 nm |
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Web Release date: July 5, 2011. |
Metal-Free Synthesis of Indanes by Iodine(III)-Mediated Ring Contraction of 1,2-Dihydronaphthalenes |
Fernanda A. Siqueira, Eloisa E. Ishikawa, André Fogaça, Andréa T. Faccio, Vânia M. T. Carneiro, Rafael R. S. Soares, Aline Utaka, Iris R. M. Tébéka, Marcin Bielawski, Berit Olofsson and
Luiz F. Silva Jr. |
| J. Braz. Chem. Soc. 2011, 22, 1795. |
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| The ring contraction of readily available 1,2-dihydronaphthalenes promoted by iodine(III) gives functionalized indanes under mild conditions |
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Web Release date: July 12, 2011. |
Dansyl-Based Fluorescent Films Prepared by Chemical and Electrochemical Methods: Cyclic Voltammetry, AFM and Spectrofluorimetry Characterization |
Ana Julia C. Silva, José Ginaldo Silva Jr., Severino Alves Jr., Josealdo Tonholo and
Adriana S. Ribeiro |
| J. Braz. Chem. Soc. 2011, 22, 1808. |
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| This scheme summarises the two methods used to prepare the fluorescent films based on dansyl derivatives and shows the images of these films when exposed to ultraviolet light |
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Web Release date: July 12, 2011. |
Background Corrected Dispersive Liquid-Liquid Microextraction of Cadmium Combined with Flame Atomic Absorption Spectrometry |
| Ghasem Karim-Nezhad, Mohammad Ahmadi and Behruz Zare-Dizajdizi |
| J. Braz. Chem. Soc. 2011, 22, 1816. |
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| Dispersive liquid-liquid micro extraction of cadmium was developed by dithizone. The organic solvents in sedimented phase made highbackground signals in flame atomic absorption spectrometry. To remove the background signals, we added 0.2 mL 0.5 mol L-1 nitric acid (strong oxidizing agent) into sedimented phase and then heated at 90 oC for 3 min until the organic solvents were evaporated completely |
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Web Release date: July 14, 2011. |
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